Treatment Resistant Depression
When traditional antidepressants haven't worked, there's still hope. We specialize in breakthrough treatments for depression that hasn't responded to standard care.
What is Treatment Resistant Depression?
Treatment-resistant depression (TRD) is defined as major depressive disorder that hasn't responded adequately to at least two different antidepressant treatments. If you've tried multiple medications without finding relief, you're not alone—approximately 30% of people with depression experience treatment resistance.
At Next Step Psychiatry, we specialize in helping patients who haven't found success with traditional treatments. As a REMS Certified Spravato® Center, we offer breakthrough therapies that work differently than conventional antidepressants.
Signs You May Have TRD
- Tried 2 or more antidepressants without adequate relief
- Depression symptoms persist despite medication compliance
- Partial response to treatment but not full remission
- Recurring depressive episodes despite treatment
- Significant impact on daily functioning and quality of life
- Feelings of hopelessness about treatment options

30%
of depression patients
experience treatment resistance
Hope When Other Treatments Haven't Worked
We offer breakthrough treatments that work through different mechanisms than traditional antidepressants
Spravato® (Esketamine)
FDA-approved nasal spray for treatment-resistant depression. Many patients experience improvement within hours to days.
Learn MoreKetamine Infusion Therapy
IV ketamine can provide rapid relief when traditional antidepressants haven't worked.
Learn MoreMedication Optimization
Advanced medication strategies including augmentation, combination therapy, and genetic testing.
Learn MoreIntegrative Approaches
Addressing underlying factors like hormonal imbalances, nutritional deficiencies, and inflammation.
Learn MoreSpecialists in Treatment Resistant Depression
REMS Certified
We're a certified Spravato® treatment center, meeting rigorous FDA safety requirements for this breakthrough therapy.
Expert Providers
Our board-certified psychiatrists have extensive experience treating complex, treatment-resistant conditions.
Rapid Results
Unlike traditional antidepressants that take weeks, our advanced treatments can show results within hours to days.
Told Spravato Isn't Covered? Give Us a Chance.
Many patients come to us after being told by other clinics that Spravato isn't covered by their insurance, that the cost is too high, or that their coverage is "too complicated" to figure out. We specialize in solving these exact problems.
Other Clinic Said No?
We've helped countless patients get approved after being denied elsewhere.
Cost Too High?
Our team navigates complex coverage to minimize your out-of-pocket costs.
Complicated Coverage?
We're experts at working with prior authorizations and appeals.
Don't Give Up on Feeling Better
If you've tried multiple antidepressants without success, there are still options. Let us help you find the treatment that works for you.