Postpartum Depression Medication: What New Mothers Should Know

Up to 19% of new mothers experience postpartum depression. At Next Step Psychiatry in Lilburn, we help new mothers throughout Gwinnett County understand their treatment options—including medication that's compatible with breastfeeding.

Common Medication Options

SSRIs

Selective serotonin reuptake inhibitors are typically first-line treatment:

• Sertraline (Zoloft) - Often preferred due to low breast milk transfer
• Fluoxetine (Prozac)
• Paroxetine (Paxil)

SNRIs

Serotonin-norepinephrine reuptake inhibitors are another option for those who don't respond to SSRIs.

Newer Options

Zurzuvae (zuranolone) is the first FDA-approved oral medication specifically for PPD. It works differently than traditional antidepressants and may provide faster relief.

Breastfeeding Considerations

Many antidepressants are compatible with breastfeeding. While small amounts may transfer to breast milk, the benefits of treating maternal depression often outweigh risks. Untreated PPD can negatively impact bonding and infant development.

Your psychiatrist and OB/GYN can help you weigh risks and benefits for your specific situation.

Finding the Right Treatment

The best medication depends on your symptoms, medical history, and whether you're breastfeeding. It may take time to find the right fit—be patient and stay in close contact with your provider.

Beyond Medication

Therapy, particularly CBT, is also highly effective for PPD and can be combined with medication for best results.