Is Wellbutrin an SSRI, SNRI, or NDRI?

By Dr. Aneel Ursani, Medical Director at Next Step Psychiatry — Lilburn, GA

If you or a loved one has been prescribed Wellbutrin—or if you're exploring antidepressant options—you may be wondering exactly what kind of medication it is. With acronyms like SSRI, SNRI, and NDRI floating around, it can feel confusing. Here at Next Step Psychiatry in Lilburn, Georgia, we believe that understanding your medication is a key part of your mental health journey.

Wellbutrin Is an NDRI—Not an SSRI or SNRI

Wellbutrin (brand name for bupropion) belongs to a class of antidepressants called NDRIs—norepinephrine and dopamine reuptake inhibitors. This sets it apart from the more commonly known SSRIs (selective serotonin reuptake inhibitors) like Lexapro or Zoloft, and SNRIs (serotonin and norepinephrine reuptake inhibitors) like Effexor.

While SSRIs and SNRIs primarily target serotonin, Wellbutrin works on two different brain chemicals: norepinephrine and dopamine. By preventing these neurotransmitters from being reabsorbed too quickly, Wellbutrin helps keep them active longer in your brain, which can improve mood, energy levels, and motivation.

What Is Wellbutrin Used For?

Bupropion is FDA-approved for treating major depressive disorder and seasonal affective disorder (SAD). Under the brand name Zyban, it is also used to help with smoking cessation. Many patients across the greater Atlanta area and Gwinnett County turn to Wellbutrin when other antidepressants haven't provided adequate relief.

At Next Step Psychiatry, our team—including Dr. Aneel Ursani and Fathima Chowdhury, PA-C—evaluates each patient individually. We consider your symptom profile, medical history, and lifestyle before recommending any medication, including Wellbutrin.

Why Choose Wellbutrin Over an SSRI?

There are several situations where Wellbutrin may be preferred:

• Fewer sexual side effects: One of the most common complaints about SSRIs is decreased libido or difficulty with sexual function. Wellbutrin is far less likely to cause these issues.
• Weight-neutral or weight loss: Unlike some SSRIs that can cause weight gain, Wellbutrin is generally weight-neutral—and some patients even experience modest weight loss.
• Fatigue and low motivation: Because Wellbutrin boosts dopamine and norepinephrine, it can be especially helpful for patients whose depression manifests as low energy and poor concentration.
• Smoking cessation: If you're trying to quit smoking while managing depression, Wellbutrin can address both.

Potential Side Effects

Like all medications, Wellbutrin can have side effects. The most common include:

• Dry mouth
• Headaches
• Insomnia or difficulty sleeping
• Nausea
• Dizziness
• Increased heart rate

In rare cases, bupropion can increase the risk of seizures, especially at higher doses. This is why working closely with a psychiatric provider is essential—dosage adjustments should always be guided by a professional.

How Long Does Wellbutrin Take to Work?

Most patients begin to notice improvements within two to four weeks, though full effects may take up to 8–12 weeks. Patience is important. We encourage our patients throughout the Lilburn and Atlanta metro area to stay in regular contact with their provider during this adjustment period rather than stopping the medication prematurely.

Finding the Right Antidepressant in Lilburn, GA

Choosing the right antidepressant is not a one-size-fits-all decision. Whether Wellbutrin, an SSRI, an SNRI, or a combination approach is best for you depends on your unique situation. At Next Step Psychiatry, we specialize in personalized medication management, including advanced treatments like Spravato for treatment-resistant depression.

If you're in the Lilburn, Lawrenceville, Tucker, or greater Gwinnett County area and want to learn more about your antidepressant options, we're here to help.

Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider before starting, stopping, or changing any medication.