Cymbalta vs. Lexapro: Choosing the Right Antidepressant

If you're struggling with anxiety or depression, your psychiatrist may discuss Cymbalta (duloxetine) or Lexapro (escitalopram) as treatment options. Both are effective, commonly prescribed antidepressants—but they work differently. Understanding these differences helps you have informed conversations with your provider.

Key Differences

FeatureLexapro (SSRI)Cymbalta (SNRI)
Drug ClassSSRI (serotonin only)SNRI (serotonin + norepinephrine)
FDA Approved ForGAD, MDDGAD, MDD, fibromyalgia, chronic pain
Pain ConditionsNot indicatedApproved for several pain conditions
Side EffectsGenerally fewerMay include blood pressure changes

Common Side Effects

Both medications share similar common side effects including drowsiness, nausea, dry mouth, sweating, and sexual dysfunction. These often improve within the first few weeks.

Which Is Better?

Neither medication is inherently superior—the "best" choice depends on your specific symptoms, medical history, and how your body responds. Some studies suggest Lexapro may be better tolerated, but individual responses vary significantly. If one doesn't work well, the other might be more effective for you.

Expert Guidance in Lilburn

Finding the right antidepressant often requires patience and professional guidance. At Next Step Psychiatry, we work with patients throughout Gwinnett County to find medications that truly work.

Schedule your consultation: 678-437-1659

4145 Lawrenceville Hwy STE 100, Lilburn, GA 30047

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